[出典] Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors" Huang TP, Zhao KT [..] Liu DR. Nat Biotechnol2019-05-20.

東大 (慶応大または神戸大兼務を含む)の研究グループは今回、nCas9 (D10A)のC末端に、PmCDA1-NLS-UGIを結合し、同時に、N末端に ...

Adenine base editors (ABEs) enable precise and efficient conversion of target A•T base pairs to G•C base pairs in genomic DNA with a minimum of by-products. While ABEs have been reported to exhibit ...

本研究针对东亚高发的心肌型法布里病致病突变IVS4+919G>A，在患者来源的成纤维细胞中，利用腺嘌呤碱基编辑工具ABEmax成功 ...

We report the cloning of a 12-year-old transgenic green fluorescent protein (GFP) monkey by somatic cell nuclear transfer (SCNT) and base editing of the embryos, accompanied with safety evaluation of ...

Genetic editing has shown great potential for the treatment of human hereditary disorders via the elimination of mutations in embryos. However, the efficiency and safety of germline gene editing are ...

Genetic editing has shown great potential for the treatment of human hereditary disorders via the elimination of mutations in embryos. However, the efficiency and safety of germline gene editing are ...

We report the cloning of a 12-year-old transgenic green fluorescent protein (GFP) monkey by somatic cell nuclear transfer (SCNT) and base editing of the embryos, accompanied with safety evaluation of ...